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Center for Theoretical Biological Physics

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Rice lab uncovers dynamics behind protein crucial in breast cancer

January 30, 2023

Just as a puppeteer moves a puppet by manipulating its strings, estrogen receptors, which play a crucial role in breast cancer, work in similar ways when they facilitate the interaction between hormones and DNA, according to Rice scientists.

people, papers, presentations

People, papers and presentations for Jan. 23, 2023

January 23, 2023

Evelyn Tang, an assistant professor of physics and astronomy and a member of Rice University’s Center for Theoretical Biological Physics, is one of 17 early-career researchers to receive a $50,000 award in the inaugural year of the Scialog: Molecular Basis of Cognition initiative, which will begin with a conference Oct. 12-15 in Tucson, Arizona.

Evelyn Tang

Evelyn Tang wins CAREER Award

December 2, 2022

Evelyn Tang, an assistant professor of physics and astronomy and a member of Rice University’s Center for Theoretical Biological Physics, has won a prestigious National Science Foundation CAREER Award.

José Onuchic wins the 2023 Founders Award presented by the Biophysical Society.

Onuchic wins top Biophysical Society honor

September 7, 2022

José Onuchic wins the 2023 Founders Award presented by the Biophysical Society.

Rice University researchers have modelled a key mechanism by which DNA replicates. The study could help identify new targets to treat disease.

Rice models moving ‘washers’ that help DNA replicate

August 9, 2022

Rice researchers model a key mechanism by which DNA replicates. The study could help identify new targets to treat disease.

Positively charged holes that propagate at catalytic sites can spread out and trigger catalysis in neighboring sectors, according to a theory developed at Rice University and the Indian Institute of Science Education and Research, Pune. (Credit: Illustration by Bhawakshi Punia and Srabanti Chaudhury/IISER Pune)

Migrating holes help catalysts be productive

January 10, 2022

A theoretical model suggests electron holes that propagate at active sites on a catalyst migrate, triggering other sites that continue the process.

Prions, aggregates implicated in neurological diseases, may also have an important function in helping regulate the transcription of messenger RNA in memory formation.

Prions may channel RNA’s messages

November 15, 2021

Prions, aggregates implicated in neurological diseases, may also have an important function in helping regulate the transcription of messenger RNA in memory formation.

A Living Systems Network

NSF extends Physics of Living Systems network at Rice

September 27, 2021

The NSF awards nearly $3 million to the Center for Theoretical Biological Physics to continue its leadership role in the Physics of Living Systems graduate research network.

Using computational models and atomic force microscope experiments, researchers at the University of Houston and Rice University have identified a possible “Achilles’ heel” in the frustration of amyloid beta peptides as they dock to the fibrils that form plaques in patients with Alzheimer’s. The frustrated steps could open a window for drugs able to cap the fibril ends, preventing further aggregation. (Credit: Illustration by Yuechuan Xu/Peter Vekilov/University of Houston)

Docking peptides, slow to lock, open possible path to treat Alzheimer’s

September 13, 2021

Researchers have identified a possible “Achilles’ heel” in the frustration of amyloid beta peptides as they dock to the fibrils that form plaques in patients with Alzheimer’s disease.

Simulations by scientists at the Rice University-based Center for Theoretical Biological Physics suggest how the SARS-CoV-2 spike infects cells. The illustration shows how the spike reconfigures itself in microseconds as it goes from pre- to post-fusion with target cells. The researchers suggest their work to reveal the mechanism by which the virus spreads could lead to new strategies to defeat COVID-19.

Sim shows how COVID virus infects cells

August 31, 2021

A simulation shows the complicated mechanism by which the SARS-CoV-2 virus may infect cells, leading to COVID-19.

Video by Esteban Dodero-Rojas and Paul Whitford/Center for Theoretical Biological Physics

Rice, Rutgers developing inhalable COVID-19 vaccine spray

July 7, 2021

Scientists at Rice and Rutgers developing two COVID-19 vaccine strategies that do not require cold storage, one of which can be inhaled.

Biologists at Baylor College of Medicine, the Netherlands Cancer Institute and Rice University show in a study published in Science that the nuclear arrangement in a human cell can be turned into that typical of a fly. (Credit: Illustration by Evgeny Gromov)

Biologists construct a ‘periodic table’ for cell nuclei

May 27, 2021

A team of biologists studying the tree of life has unveiled a new classification system for cell nuclei, and discovered a method for transmuting one type of cell nucleus into another.

Amyloid

Cancer ‘guardian’ breaks bad with one switch

March 5, 2021

A mutation that replaces a single amino acid in a potent tumor-suppressing protein makes it prone to nucleating amyloid fibrils implicated in many cancers as well as neurological diseases.

3D illustration of the bacterial pathogen Mycobacterium tuberculosis.

Study could explain tuberculosis bacteria paradox

February 22, 2021

Tuberculosis bacteria have evolved to remember stressful encounters and react quickly to future stress, according to a study by computational bioengineers at Rice University and infectious disease experts at Rutgers New Jersey Medical School.

Propofol B

Study shows why anesthetic stops cell’s walkers in their tracks

January 28, 2021

Researchers detail the mechanism that allows propofol, a common anesthetic, to halt the movement of kinesin proteins that deliver cargoes to the far reaches of cells.

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