Preventing life-threatening pediatric condition starts with pandemic safeguards                   

Early identification of children’s syndrome after COVID-19 infection is crucial, Rice researchers say  

Children with Mask

HOUSTON – (May 12, 2021) – Adults can be the first line of defense when it comes to avoiding the worst outcomes from multisystem inflammatory syndrome in children (MIS-C), a rare but potentially deadly condition linked to COVID-19, according to a new review article from Rice University epidemiologists.

"It's important to educate people about MIS-C, especially the fact that it can develop 2-6 weeks after children recover from COVID-19," said Texas Policy Lab researcher E. Susan Amirian. "Some people assume once a child recovers from COVID-19, things will go back to normal. But this isn't necessarily the case. We want parents, teachers and caregivers to know what to look out for."

In the article, "Multisystem inflammatory syndrome in children (MIS-C) and the coronavirus pandemic: Current knowledge and implications for public health,” Amirian and colleague Megan Rafferty raise awareness of the condition and emphasize continued COVID-19 mitigation efforts both in schools and at home. Helping children take appropriate precautions to prevent COVID-19 infection and transmission is crucial, Amirian said.

MIS-C causes organ inflammation, according to the Centers for Disease Control and Prevention (CDC). Most children make a full recovery, but the condition can be deadly.

Symptoms include fever, rash, vomiting and diarrhea, typically appearing 2-6 weeks following a SARS-CoV-2 infection. As of late March, the CDC had reports of 3,185 cases of MIS-C nationwide.

"Even though MIS-C is rare and treatable, some kids end up in ICU and have some pretty severe outcomes, such as heart problems including heart failure," Amirian said. Early diagnosis and treatment of MIS-C can help prevent such serious outcomes.

Rafferty said researchers aren't sure why some children develop MIS-C and others do not. In addition, the number of undetected COVID-19 infections in kids can make it difficult to determine who is at risk.

"Because children are more likely to have mild or asymptomatic (COVID-19) infections, the proportion of undiagnosed cases can be high, so some children may develop MIS-C with little to no forewarning," Rafferty said.

As new, more contagious variants of COVID-19 emerge, Amirian said effective preventative measures should be maintained to mitigate the spread of the virus, especially until vaccines become available to younger children.

"We don’t yet know exactly what the impact of these variants will be on MIS-C risk, but as we’re seeing in states like Michigan, COVID-19 cases are increasing among younger populations, so preventing infection remains an important goal for both kids and adults," Amirian said.

The study is available at It was published in the Journal of Infection and Public Health.


This news release can be found online at

Follow Rice News and Media Relations on Twitter @RiceUNews.

Photo link:

Photo credit:

Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,978 undergraduates and 3,192 graduate students, Rice’s undergraduate student-to-faculty ratio is just under 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for lots of race/class interaction and No. 1 for quality of life by the Princeton Review. Rice is also rated as a best value among private universities by Kiplinger’s Personal Finance.